Hydrochloric Acid → HCID 178478894, compound

HRID 1723159Notes

Reaction equation

HRID 1723159 reaction equation
[N:1]1([CH2:6][C:7]2[CH:26]=[CH:25][C:10]3[NH:11][C:12]([C:14]4[CH:24]=[CH:23][C:17]([C:18]([O:20]CC)=[O:19])=[CH:16][CH:15]=4)=[N:13][C:9]=3[CH:8]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.[ClH:27]>>[ClH:27].[ClH:27].[N:1]1([CH2:6][C:7]2[CH:26]=[CH:25][C:10]3[NH:11][C:12]([C:14]4[CH:24]=[CH:23][C:17]([C:18]([OH:20])=[O:19])=[CH:16][CH:15]=4)=[N:13][C:9]=3[CH:8]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 178468753HCID 178468753, compound

Product 1

HCID 178478894HCID 178478894, compoundYield 59%

Procedure

A mixture of 3 parts of ethyl 4-[5-(1H-imidazol-1-ylmethyl)-1H-benzimidazol-2-yl]benzoate and 50 parts of a hydrochloric acid solution 6N was stirred and refluxed for 12 hours. The reaction mixture was evaporated to dry. The residue was taken up in 2 parts of water and 2-propanone. The product was filtered off and dried, yielding 2 parts (59%) of 4-[5-(1H-imidazol-1-ylmethyl)-1H-benzimidazol-2-yl]benzoic acid dihydrochloride. monohydrate; mp. 288.2° C. (compound 259).

Workup

  1. temperaturerefluxed for 12 hours
  2. customThe reaction mixture was evaporated
  3. customto dry
  4. filtrationThe product was filtered off
  5. customdried

Sources & evidence

ORD record
ord-431d7dd3bfbd44dca0685b0ed2650e33
Source dataset
uspto-grants-1989_08
Patent number
US04859684

Reaction notes

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