Potassium Carbonate → HCID 178526974, compound

Participants

Reaction Steps

To a stirred and heated (60° C.) solution of 8 parts of 5-(1H-imidazol-1-ylmethyl)-1H-benzimidazole-2-methanol, 4.7 parts of potassium carbonate and 100 parts of water were added portionwise 11.1 parts of potassium permanganate. Upon completion, stirring was continued for 15 minutes at 60° C. The manganese(IV) oxide was filtered off over diatomaceous earth. After cooling, the filtrate was treated with glacial acetic acid to pH 5.5. The whole was evaporated to dry. The residue was taken up in a small amount of water. The product was filtered off and dried for 24 hours, yielding 3.1 parts (31.8%) of 5-(1H-imidazol-1-ylmethyl)-1H-benzimidazole-2-carboxylic acid dihydrate (compound 265).

Provenance & Evidence