Potassium Carbonate → HCID 178526974, compound

HRID 1723161Notes

Reaction equation

HRID 1723161 reaction equation
[N:1]1([CH2:6][C:7]2[CH:17]=[CH:16][C:10]3[NH:11][C:12]([CH2:14][OH:15])=[N:13][C:9]=3[CH:8]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.C(=O)([O-])[O-:19].[K+].[K+].[Mn]([O-])(=O)(=O)=[O:25].[K+]>O>[OH2:15].[OH2:19].[N:1]1([CH2:6][C:7]2[CH:17]=[CH:16][C:10]3[NH:11][C:12]([C:14]([OH:25])=[O:15])=[N:13][C:9]=3[CH:8]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 516875Potassium PermanganateHCID 178519936HCID 178519936, compound

Product 1

HCID 178526974HCID 178526974, compoundYield 31.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a stirred and heated (60° C.) solution of 8 parts of 5-(1H-imidazol-1-ylmethyl)-1H-benzimidazole-2-methanol, 4.7 parts of potassium carbonate and 100 parts of water were added portionwise 11.1 parts of potassium permanganate. Upon completion, stirring was continued for 15 minutes at 60° C. The manganese(IV) oxide was filtered off over diatomaceous earth. After cooling, the filtrate was treated with glacial acetic acid to pH 5.5. The whole was evaporated to dry. The residue was taken up in a small amount of water. The product was filtered off and dried for 24 hours, yielding 3.1 parts (31.8%) of 5-(1H-imidazol-1-ylmethyl)-1H-benzimidazole-2-carboxylic acid dihydrate (compound 265).

Workup

  1. stirringUpon completion, stirring
  2. filtrationThe manganese(IV) oxide was filtered off over diatomaceous earth
  3. temperatureAfter cooling
  4. additionthe filtrate was treated with glacial acetic acid to pH 5.5
  5. customThe whole was evaporated
  6. customto dry
  7. filtrationThe product was filtered off
  8. customdried for 24 hours

Sources & evidence

ORD record
ord-5bef831a5b5d484eac718a14d312028c
Source dataset
uspto-grants-1989_08
Patent number
US04859684

Reaction notes

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