Trifluoroacetic acid → HCID 88618839, compound

HRID 1723173Notes

Reaction equation

HRID 1723173 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:15]2[CH:20]=[CH:19][C:18]([O:21][C:22]([F:25])([F:24])[F:23])=[CH:17][CH:16]=2)=[C:5]([CH3:14])[C:6]=1C(OC(C)(C)C)=O.[F:26][C:27]([F:32])([F:31])[C:28]([OH:30])=[O:29]>C1(C)C=CC=CC=1>[F:26][C:27]([F:32])([F:31])[C:28]([OH:30])=[O:29].[NH2:1][C:2]1[S:3][C:4]([C:15]2[CH:16]=[CH:17][C:18]([O:21][C:22]([F:24])([F:23])[F:25])=[CH:19][CH:20]=2)=[C:5]([CH3:14])[CH:6]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 20026749HCID 20026749, compound

Product 1

HCID 88618839HCID 88618839, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The above thiophene (0.7 g) in 6 ml of trifluoroacetic acid is heated to 60° C. for 3 hr., cooled, diluted with toluene and concentrated in vacuo. The resulting oil is diluted and concentated twice more to afford 2-amino-4-methyl-5-(4-trifluoromethyloxyphenyl)thiophene trifluoroacetic acid salt.

Workup

  1. temperature, cooled
  2. concentrationconcentrated in vacuo
  3. additionThe resulting oil is diluted

Sources & evidence

ORD record
ord-c35d847495c84f628c381a82efde89b5
Source dataset
uspto-grants-1989_08
Patent number
US04859699

Reaction notes

Loading…