Cyanamide → HCID 53635162, compound

HRID 1723250Notes

Reaction equation

HRID 1723250 reaction equation
[N:1]#[C:2][NH2:3].[CH:4]([C:7]1[CH:12]=[C:11]([O:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:10]=[C:9]([CH:20]([CH3:22])[CH3:21])[C:8]=1[N:23]=[C:24]=[N:25][C:26]([CH3:29])([CH3:28])[CH3:27])([CH3:6])[CH3:5]>ClCCCl>[C:2]([NH:3][C:24]([NH:23][C:8]1[C:9]([CH:20]([CH3:22])[CH3:21])=[CH:10][C:11]([O:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:12][C:7]=1[CH:4]([CH3:6])[CH3:5])=[N:25][C:26]([CH3:29])([CH3:27])[CH3:28])#[N:1]

Participants

4

Reactant 2

HCID 9864CyanamideHCID 21760452HCID 21760452, compound2×

Product 1

HCID 53635162HCID 53635162, compound

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

0.46 g of cyanamide are added to a solution of 3.5 g of N-(2,6-diisopropyl-4-phenoxyphenyl)-N'-tert-butylcarbodiimide [prepared in accordance with Example 1 (compound 4) of European patent application A-175 649] in 20 ml of 1,2-dichloroethane. The reaction mixture is refluxed for 21 hours and then concentrated by evaporation to a suspension. This concentrated suspension is stirred with diethyl ether and the crystalline product so obtained is filtered with suction. Melting point 206°-207° C. (recrystallisation from diethyl ether/hexane).

Workup

  1. temperatureThe reaction mixture is refluxed for 21 hours
  2. concentrationconcentrated by evaporation to a suspension
  3. customthe crystalline product so obtained
  4. filtrationis filtered with suction
  5. customMelting point 206°-207° C. (recrystallisation from diethyl ether/hexane)

Sources & evidence

ORD record
ord-dc0bc8f9602940c0b81cd9867d5fafe4
Source dataset
uspto-grants-1989_08
Patent number
US04859761

Reaction notes

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