Methyl iodide → 1-(3,5-Difluorobenzyl)-2-methylmercaptoimidazole-5-carboxylic acid

HRID 1723269Notes

Reaction equation

HRID 1723269 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:15]=[C:16]([F:18])[CH:17]=1)[CH2:5][N:6]1[C:10]([C:11]([OH:13])=[O:12])=[CH:9][N:8]=[C:7]1[SH:14].[CH3:19]I.C[O-].[Na+]>CO>[F:1][C:2]1[CH:3]=[C:4]([CH:15]=[C:16]([F:18])[CH:17]=1)[CH2:5][N:6]1[C:10]([C:11]([OH:13])=[O:12])=[CH:9][N:8]=[C:7]1[S:14][CH3:19]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 10942334Sodium MethoxideHCID 178524783HCID 178524783, compound

Product 1

HCID 147697341-(3,5-Difluorobenzyl)-2-methylmercaptoimidazole-5-carboxylic acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Reaction of 1-(3,5-difluorobenzyl)-2-mercaptoimidazole-5-carboxylic acid prepared as in Example 1 with methyl iodide and sodium methoxide in methanol by standard techniques yields 1-(3,5-difluorobenzyl)-2-methylmercaptoimidazole-5-carboxylic acid.

Sources & evidence

ORD record
ord-2428c5cfb6f04bf9a749ce8f24b9406a
Source dataset
uspto-grants-1989_08
Patent number
US04859779

Reaction notes

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