Maleic Acid → HCID 67885494, compound

HRID 1723303Notes

Reaction equation

HRID 1723303 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:14]=1[N:13]([CH3:15])[C:12]1[CH2:11][CH2:10][CH:9]([CH2:16][C:17]3[N:18]=[CH:19][NH:20][C:21]=3[CH3:22])[C:8](=[O:23])[C:7]2=1.[C:24]([OH:31])(=[O:30])/[CH:25]=[CH:26]\[C:27]([OH:29])=[O:28]>C(OCC)(=O)C.C(O)C>[C:24]([OH:31])(=[O:30])/[CH:25]=[CH:26]\[C:27]([OH:29])=[O:28].[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:14]=1[N:13]([CH3:15])[C:12]1[CH2:11][CH2:10][CH:9]([CH2:16][C:17]3[N:18]=[CH:19][NH:20][C:21]=3[CH3:22])[C:8](=[O:23])[C:7]2=1

Participants

5

Reactant 2

HCID 444266Maleic AcidHCID 19769827HCID 19769827, compound

Product 1

HCID 67885494HCID 67885494, compoundYield 77.7%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

8-Fluoro-1,2,3,9-tetrahydro-9-methyl-3-[(5-methyl-1H-imidazol-4-yl)-methyl]-4H-carbazol-4-one (1.51 g) was dissolved in ethyl acetate (40 ml), and added to a solution of maleic acid (563 mg) in ethanol (50 ml). The solution was cooled to 0°, and the resultant solid was filtered off and dried in vacuo to give the title compound (1.61 g), m.p. 155°-158°, t.l.c. (System A 100:8:1), Rf 0.43.

Workup

  1. temperatureThe solution was cooled to 0°
  2. filtrationthe resultant solid was filtered off
  3. customdried in vacuo

Sources & evidence

ORD record
ord-d89a4a3913bc461f9afefe12078174ae
Source dataset
uspto-grants-1989_08
Patent number
US04859662

Reaction notes

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