4-(2-Chloroethyl)morpholine → 2-(2-Morpholinoethylthio)-3-phenyl-4(3H)-quinazolinone

HRID 1723331Notes

Reaction equation

HRID 1723331 reaction equation
[SH:1][C:2]1[N:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:10](=[O:18])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.Cl[CH2:20][CH2:21][N:22]1[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1>>[O:25]1[CH2:26][CH2:27][N:22]([CH2:21][CH2:20][S:1][C:2]2[N:11]([C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=3)[C:10](=[O:18])[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]=2)[CH2:23][CH2:24]1

Participants

3

Reactant 2

HCID 767274-(2-Chloroethyl)morpholineHCID 178515047HCID 178515047, compound

Product 1

HCID 145751552-(2-Morpholinoethylthio)-3-phenyl-4(3H)-quinazolinoneYield 49.8%

Procedure

The title compound was prepared in a yield of 49.8%, using 2-mercapto-3-phenyl-4(3H)-quinazolinone in place of 3-isobutyl-2-mercapto-4(3H)-quinazolinone and N-(2chloroethyl)morpholine in place of 2-chloromethylpyridine hydrochloride.

Sources & evidence

ORD record
ord-e01b637d7978480482d83eb335aeb987
Source dataset
uspto-grants-1989_08
Patent number
US04861780

Reaction notes

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