HCID 9851847, compound → HCID 9830786, compound

HRID 1723476Notes

Reaction equation

HRID 1723476 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][C@H:9]2[C:15]([O:17][CH3:18])=[O:16])=[CH:4][CH:3]=1.C[O-].[Na+]>C1(C)C=CC=CC=1>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]2[CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][C@H:9]2[C:15]([O:17][CH3:18])=[O:16])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 9851847HCID 9851847, compoundHCID 10942334Sodium Methoxide

Product 1

HCID 9830786HCID 9830786, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

(±)-cis-4-(4'-Fluorophenyl)-3-methoxycarbonyl-1-methylpiperidine (2.0 g), prepared as in Example 2(a), in dry toluene was added to sodium methoxide in toluene and refluxed for 7 hours. After cooling to 0° and filtration, evaporation gave the title compound as an oil (1.97 g, 99%), purity 85-90%.

Workup

  1. temperaturerefluxed for 7 hours
  2. temperatureAfter cooling to 0°
  3. filtrationfiltration, evaporation

Sources & evidence

ORD record
ord-a22e1a6eb88243058ccc511309987fc4
Source dataset
uspto-grants-1989_08
Patent number
US04861893

Reaction notes

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