Hydrogen Bromide → HCID 13731500, compound

HRID 1723498Notes

Reaction equation

HRID 1723498 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH:10]2[CH3:15])=[CH:5][CH:4]=1.[BrH:16]>O>[BrH:16].[BrH:16].[CH3:15][CH:10]1[CH2:11][NH:12][CH2:13][CH2:14][N:9]1[C:6]1[CH:7]=[CH:8][C:3]([OH:2])=[CH:4][CH:5]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 27237771-(4-Methoxyphenyl)-2-methylpiperazine

Product 1

HCID 13731500HCID 13731500, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 43 parts of 1-(4-methoxyphenyl)-2-methylpiperazine and 375 parts of a hydrobromic acid solution 48% in water was stirred and refluxed overnight. The reaction mixture was evaporated and the residue was crystallized from 2-propanol. The product was filtered off and dried, yielding 72 parts (97%) of 4-(2-methyl-1-piperazinyl)phenol dihydrobromide (77).

Workup

  1. temperaturerefluxed overnight
  2. customThe reaction mixture was evaporated
  3. customthe residue was crystallized from 2-propanol
  4. filtrationThe product was filtered off
  5. customdried

Sources & evidence

ORD record
ord-f6c276cf1d474bd084972d40de5582d4
Source dataset
uspto-grants-1989_08
Patent number
US04861879

Reaction notes

Loading…