1-Methylpiperazine → HCID 9969852, compound

HRID 1723503Notes

Reaction equation

HRID 1723503 reaction equation
ClCCCO[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1/[CH:12]=[CH:13]/[C:14]1[O:15][C:16]2[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=2[N:18]=1.[CH3:23][N:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1>>[CH3:23][N:24]1[CH2:29][CH2:28][N:27]([CH2:12][CH2:13][CH2:14][O:15][C:9]2[CH:8]=[C:7](/[CH:12]=[CH:13]/[C:14]3[O:15][C:16]4[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=4[N:18]=3)[CH:6]=[CH:11][CH:10]=2)[CH2:26][CH2:25]1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 20025807HCID 20025807, compound

Product 1

HCID 9969852HCID 9969852, compound

Procedure

The title compound was prepared as described in Example 1 starting with (A) of Example 1 (2.0 g, 6.4 mmol) and using N-methylpiperazine in place of dibutylamine to produce 0.56 g (25% yield of the free base of the title compound which was converted to the HCl salt, mp 250°-252° C. IR: 1600 cm-1. MS: 378(MH+). 1H NMR (CDCl3): δ 7.82-7.00 (m, 10H), 4.13 (t, J=5.2 Hz, 2H), 3.31 (m, 13H), 2.41 (m, 2H).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-8d2e4fa9f3b24b82b383c59c2e02b557
Source dataset
uspto-grants-1989_08
Patent number
US04861897

Reaction notes

Loading…