反应详情

To a solution of ethyl 2-cyclopropyloxyimino-3,3-ethylenedioxybutyrate (syn isomer)(487 mg) in methylene chloride (0.8 ml) was added 90% trifluoroacetic acid (0.8 ml) under ice-cooling. The mixture was stirred at ambient temperature for 2 hours. The mixture was concentrated in vacuo to give a residue. The residue was dissolved in diethyl ether and washed successively with saturated aqueous solution of sodium bicarbonate and water, dried over magnesium sulfate and concentrated in vacuo to give ethyl 2-cyclopropyloxyimino-3-oxobutyrate (syn isomer)(382 mg) as an oil.

1. temperaturecooling
2. concentrationThe mixture was concentrated in vacuo
3. customto give a residue
4. washwashed successively with saturated aqueous solution of sodium bicarbonate and water
5. dry with materialdried over magnesium sulfate
6. concentrationconcentrated in vacuo