Ethyl 3-Hydroxybutyrate → Ethyl (R)-(+)-4-bromo-3-hydroxybutyrate

HRID 1723613Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1723613
OC(C)CC(OCC)=O.[Br:10][CH2:11][CH:12]([OH:19])[CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15]>>[Br:10][CH2:11][C@H:12]([OH:19])[CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15]

Komponenten

3

Edukt 2

HCID 62572Ethyl 3-HydroxybutyrateHCID 3432354HCID 3432354, Verbindung

Produkt 1

HCID 12408095Ethyl (R)-(+)-4-bromo-3-hydroxybutyrateAusbeute 99 %

Versuchsvorschrift

Instead of ethyl 3-hydroxybutyrate used in Example 1, ethyl 4-bromo-3-hydroxybutyrate (1%, w/v) was used as a reactant and novozyme 435 lipase was used as a biocatalyst. After reaction for 1 hour 40 minutes, ethyl (R)-4-bromo-3-hydroxybutyrate (99% e.e) was obtained at 88.3% conversion.

Aufarbeitung

  1. customAfter reaction for 1 hour 40 minutes

Quellen und Nachweise

ORD-Eintrag
ord-7ff8bda6f454415db024575f072a4f43
Quelldatensatz
uspto-grants-2009_02
Patentnummer
US07485452B2

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