HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-Hydroxybutyrate → Ethyl (R)-(+)-4-bromo-3-hydroxybutyrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-Hydroxybutyrate | HCID 62572 | — |
| Reactant | Ethyl 4-bromo-3-hydroxybutanoate | HCID 3432354 | — |
| Product | Ethyl (R)-(+)-4-bromo-3-hydroxybutyrate | HCID 12408095 | 99% |
Reaction Steps
Instead of ethyl 3-hydroxybutyrate used in Example 1, ethyl 4-bromo-3-hydroxybutyrate (1%, w/v) was used as a reactant and novozyme 435 lipase was used as a biocatalyst. After reaction for 1 hour 40 minutes, ethyl (R)-4-bromo-3-hydroxybutyrate (99% e.e) was obtained at 88.3% conversion.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07485452B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-7ff8bda6f454415db024575f072a4f43 |
| Source note | uspto-grants-2009_02 |