Ethyl isothiocyanatoformate → HCID 178473562, compound

HRID 1723621Notes

Reaction equation

HRID 1723621 reaction equation
[C:1]([O:5][C:6](=[O:15])[NH:7][CH:8]1[CH2:13][CH2:12][CH:11]([NH2:14])[CH2:10][CH2:9]1)([CH3:4])([CH3:3])[CH3:2].[CH2:16]([O:18][C:19]([N:21]=[C:22]=[S:23])=[O:20])[CH3:17]>>[C:1]([O:5][C:6](=[O:15])[NH:7][C@H:8]1[CH2:9][CH2:10][C@H:11]([NH:14][C:22]([NH:21][C:19]([O:18][CH2:16][CH3:17])=[O:20])=[S:23])[CH2:12][CH2:13]1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 85320Ethyl isothiocyanatoformateHCID 2756050Cis tert-Butyl 4-aminocyclohexylcarbamate

Product 1

HCID 178473562HCID 178473562, compound

Procedure

To a solution of 1.10 g of (4-amino-cyclohexyl)-carbamic acid tert-butyl ester in 25 ml of EtAc 0.58 ml of ethoxycarbonyl-isothiocyanat are added and the mixture obtained is stirred at RT. The precipitate formed is filtered and washed with diethylether. [trans-4-(3-Ethoxycarbonyl-thioureido)cyclohexyl]carbamic acid tert-butyl ester is obtained.

Workup

  1. customthe mixture obtained
  2. customThe precipitate formed
  3. filtrationis filtered
  4. washwashed with diethylether

Sources & evidence

ORD record
ord-3dbeb131fff14f5c8f875c9d5060d5c9
Source dataset
uspto-grants-2009_02
Patent number
US07485632B2

Reaction notes

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