Methyl iodide → HCID 178504046, compound

HRID 1723623Notes

Reaction equation

HRID 1723623 reaction equation
[C:1]([O:5][C:6](=[O:18])[NH:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([NH:14][C:15]([NH2:17])=[S:16])[CH2:10][CH2:9]1)([CH3:4])([CH3:3])[CH3:2].[CH3:19]I>CO>[C:1]([O:5][C:6](=[O:18])[NH:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([NH:14][C:15](=[NH:17])[S:16][CH3:19])[CH2:10][CH2:9]1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 178454037HCID 178454037, compound

Product 1

HCID 178504046HCID 178504046, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 1.19 g of (trans-4-thioureido-cyclohexyl)-carbamic acid tert-butyl ester and 0.41 ml of methyliodide in 50 ml of MeOH is stirred at RT. From the mixture obtained solvent is evaporated and [trans-4-(2-methyl-isothioureido)-cyclohexyl]-carbamic acid tert-butyl ester in the form of a hydrolodide is obtained.

Workup

  1. customFrom the mixture obtained solvent
  2. customis evaporated

Sources & evidence

ORD record
ord-941be3564bea4ff8bf63eedef6b4b1ab
Source dataset
uspto-grants-2009_02
Patent number
US07485632B2

Reaction notes

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