Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → Hydrochloric Acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | 1-(4-Dimethylaminocyclohexyl)-3-methyl-thiourea | HCID 4221637 | — |
| 용매 | Chloride | HCID 312 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Hydrochloric Acid | HCID 313 | — |
| 생성물 | HCID 178485022 | HCID 178485022 | — |
반응 단계
A mixture of 0.50 g of 1-(4-dimethylaminocyclohexyl)-3-methyl-thiourea in 10 ml of MeOH, 1.16 ml of 2M HCl (in MeOH) and 0.36 g of methyliodide is stirred at RT. From the mixture obtained solvent is evaporated and the evaporation residue obtained is treated with H2O. 10 ml of a strong basic ion exchanger in chloride form (Amberlite IRA 400 (Cl)R) are added to the aqueous mixture obtained and the mixture obtained is stirred at RT. A precipitate obtained is filtrated off and the filtrate obtained is lyophilized. 1-(trans-4-Dimethylamino-cyclohexyl)-2,3-dimethyl-isothiourea in the form of a hydrochloride is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07485632B2 |
| 출처 데이터셋 | uspto-grants-2009_02 |
| ORD ID | ord-6865711830564f9ba16c6da1dc7ac535 |
| 출처 메모 | uspto-grants-2009_02 |