Hydrochloric Acid → Hydrochloric Acid

HRID 1723625노트

반응식

HRID 1723625 반응식
[CH3:1][N:2]([CH3:14])[CH:3]1[CH2:8][CH2:7][CH:6]([NH:9][C:10]([NH:12][CH3:13])=[S:11])[CH2:5][CH2:4]1.[CH3:15]I.O.[ClH:18]>CO.[Cl-]>[CH3:1][N:2]([CH3:14])[C@H:3]1[CH2:4][CH2:5][C@H:6]([NH:9][C:10](=[N:12][CH3:13])[S:11][CH3:15])[CH2:7][CH2:8]1.[ClH:18]

참가 물질

8

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 6328Methyl iodideHCID 42216371-(4-Dimethylaminocyclohexyl)-3-methyl-thiourea

생성물 2

HCID 313Hydrochloric AcidHCID 178485022HCID 178485022, 화합물

시약·촉매·용매 2

HCID 312Chloride용매HCID 887Methanol용매

실험 절차

A mixture of 0.50 g of 1-(4-dimethylaminocyclohexyl)-3-methyl-thiourea in 10 ml of MeOH, 1.16 ml of 2M HCl (in MeOH) and 0.36 g of methyliodide is stirred at RT. From the mixture obtained solvent is evaporated and the evaporation residue obtained is treated with H2O. 10 ml of a strong basic ion exchanger in chloride form (Amberlite IRA 400 (Cl)R) are added to the aqueous mixture obtained and the mixture obtained is stirred at RT. A precipitate obtained is filtrated off and the filtrate obtained is lyophilized. 1-(trans-4-Dimethylamino-cyclohexyl)-2,3-dimethyl-isothiourea in the form of a hydrochloride is obtained.

후처리

  1. customFrom the mixture obtained solvent
  2. customis evaporated
  3. customthe evaporation residue obtained
  4. customobtained
  5. customthe mixture obtained
  6. stirringis stirred at RT
  7. customA precipitate obtained
  8. filtrationis filtrated off
  9. customthe filtrate obtained

출처 및 근거

ORD 기록
ord-6865711830564f9ba16c6da1dc7ac535
출처 데이터셋
uspto-grants-2009_02
특허 번호
US07485632B2

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