HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1723642Generated: November 1, 2026
Trifluoroacetic acid → Pyridine, 1,2,3,6-tetrahydro-4-[4-(trifluoromethyl)phenyl]-
https://huagongshe.com/reaction/1723642
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-butyl 4-(4-(trifluoromethyl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate | HCID 18364827 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Pyridine, 1,2,3,6-tetrahydro-4-[4-(trifluoromethyl)phenyl]- | HCID 12440708 | — |
Reaction Steps
A mixture of 0.52 mmol 4-(4-trifluoromethyl-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester in 2 ml dichloromethane was treated with 0.2 ml trifluoroacetic acid. The mixture was stirred at 40° C. for 3 hrs then concentrated and treated with water/NaOH and extracted with dichloromethane. The combined organic phases were washed with saturated NaCl, dried with MgSO4 and evaporated to yield the title compound. MS (m/e): 228.3 (MH+, 100%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07485637B2 |
|---|
| Source dataset | uspto-grants-2009_02 |
|---|
| ORD ID | ord-58cd6dd3f0924ee499d3256960bc9e9e |
|---|
| Source note | uspto-grants-2009_02 |
|---|
