反应详情

温度

40 °C

A mixture of 0.52 mmol 4-(4-trifluoromethyl-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester in 2 ml dichloromethane was treated with 0.2 ml trifluoroacetic acid. The mixture was stirred at 40° C. for 3 hrs then concentrated and treated with water/NaOH and extracted with dichloromethane. The combined organic phases were washed with saturated NaCl, dried with MgSO4 and evaporated to yield the title compound. MS (m/e): 228.3 (MH+, 100%)

1. concentrationthen concentrated
2. additiontreated with water/NaOH
3. extractionextracted with dichloromethane
4. washThe combined organic phases were washed with saturated NaCl
5. dry with materialdried with MgSO4
6. customevaporated