HCID 57434154, compound → HCID 68871245, compound

HRID 1723670Notes

Reaction equation

HRID 1723670 reaction equation
Br[C:2]1[N:6]2[CH:7]=[CH:8][N:9]([CH2:12][CH3:13])[C:10](=[O:11])[C:5]2=[N:4][CH:3]=1.[F:14][C:15]1[CH:20]=[CH:19][C:18](B(O)O)=[CH:17][C:16]=1[O:24][CH2:25][C:26]1[N:27]([CH3:31])[N:28]=[CH:29][N:30]=1>>[CH2:12]([N:9]1[CH:8]=[CH:7][N:6]2[C:2]([C:18]3[CH:19]=[CH:20][C:15]([F:14])=[C:16]([O:24][CH2:25][C:26]4[N:27]([CH3:31])[N:28]=[CH:29][N:30]=4)[CH:17]=3)=[CH:3][N:4]=[C:5]2[C:10]1=[O:11])[CH3:13]

Participants

3

Reactant 2

HCID 57434154HCID 57434154, compoundHCID 68871757HCID 68871757, compound

Product 1

HCID 68871245HCID 68871245, compoundYield 23%

Procedure

3-Bromo-7-ethyl-7H-imidazo[1,2-a]pyrazin-8-one and 4-fluoro-3-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)benzeneboronic acid were coupled to give the title compound as a white solid (43 mg, 23%): δH (400 MHz, d6-DMSO) 1.26 (3H, t, J 7), 3.94 (3H, s), 3.96 (2H, s), 5.52 (2H, s), 7.22-7.26 (2H, m), 7.44 (1H, dd, J 11 and 8), 7.65 (1H, d, J 6), 7.64 (1H, dd, J 8 and 2), 7.66 (1H, s), 7.98 (1H, s); m/z (ES+) 369 [M+H]+.

Sources & evidence

ORD record
ord-be2110edb5a244d5bfe9323424d42015
Source dataset
uspto-grants-2009_02
Patent number
US07485640B2

Reaction notes

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