反应详情

Crude tert-butyl 4-[4-(2,2,2-trifluoroethoxy)phenyl]piperazine-1-carboxylate (32.47 g, approx 57 mmol) was dissolved in DCM (300 ml) and TFA (69 mL) was added. The reaction was stirred at room temperature overnight then evaporated to dryness, azeotroping with toluene. The residue was partitioned between DCM and saturated sodium bicarbonate solution. The organic phase was separated, dried (MgSO4), filtered and concentrated to yield 1-[4-(2,2,2-trifluoroethoxy)phenyl]piperazine as a solid (13.48 g, 91%)

1. customthen evaporated to dryness
2. customazeotroping with toluene
3. customThe residue was partitioned between DCM and saturated sodium bicarbonate solution
4. customThe organic phase was separated
5. dry with materialdried (MgSO4)
6. filtrationfiltered
7. concentrationconcentrated