反应详情

温度

0 °C

1-[4-(2,2,2-trifluoroethoxy)phenyl]piperazine (13.48 g, 50 mmol) was dissolved in DCM (500 mL) and cooled to 0° C. Triethylamine (29 mL, 0.2 mol) was added, followed by the dropwise addition of methanesulfonyl chloride (4.2 mL, 55 mmol). The reaction was then allowed to warm to room temperature and stir overnight, before being quenched by the addition of water. The layers were separated, and the organic phase dried (MgSO4), filtered and concentrated. The residue was recrystallised from hot ethanol to give pure 1-(methylsulfonyl)-4-[4-(2,2,2-trifluoroethoxy)phenyl]piperazine (3.3 g, 18%).

1. temperatureto warm to room temperature
2. custombefore being quenched by the addition of water
3. customThe layers were separated
4. dry with materialthe organic phase dried (MgSO4)
5. filtrationfiltered
6. concentrationconcentrated
7. customThe residue was recrystallised from hot ethanol