HCID 68825810, compound → HCID 11603433, compound

HRID 1723923Notes

Reaction equation

HRID 1723923 reaction equation
N1(C2C=CC(C([N:13]3[C:17]4[CH:18]=[C:19]([C:21]([O:23][CH3:24])=[O:22])[S:20][C:16]=4[C:15]([NH:25][C:26](=[O:39])[C:27]4[CH:32]=[CH:31][C:30]([N:33]5[CH2:38][CH2:37][O:36][CH2:35][CH2:34]5)=[CH:29][CH:28]=4)=[N:14]3)=O)=CC=2)CCOCC1>CO.CCN(CC)CC>[N:33]1([C:30]2[CH:31]=[CH:32][C:27]([C:26]([NH:25][C:15]3[C:16]4[S:20][C:19]([C:21]([O:23][CH3:24])=[O:22])=[CH:18][C:17]=4[NH:13][N:14]=3)=[O:39])=[CH:28][CH:29]=2)[CH2:34][CH2:35][O:36][CH2:37][CH2:38]1

Participants

4

Reactant 1

HCID 68825810HCID 68825810, compound

Product 1

HCID 11603433HCID 11603433, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8471TriethylamineSolvent

Procedure

A mixture of methyl 1-(4-morpholin-4-ylbenzoyl)-3-[(4-morpholin-4-ylbenzoyl)amino]-1H-thieno[3,2-c]pyrazole-5-carboxylate (4.3 g, 7.5 mmol) in MeOH (200 ml) and Et3N (20 ml) was refluxed for 8 h. After cooling the precipitate was separated by filtration and triturated with hot methyl alcohol. After filtration and drying at 40° C. under vacuum 2.4 g of title compound were obtained. LC-MS, chromatographic method A, Rt 4.52, [M+H]+ 387.

Workup

  1. temperaturewas refluxed for 8 h
  2. temperatureAfter cooling the precipitate
  3. customwas separated by filtration
  4. customtriturated with hot methyl alcohol
  5. filtrationAfter filtration
  6. dry with materialdrying at 40° C. under vacuum 2.4 g of title compound
  7. customwere obtained

Sources & evidence

ORD record
ord-6cef4982899f4cbcb08b0caa881bbbae
Source dataset
uspto-grants-2009_02
Patent number
US07485661B2

Reaction notes

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