1-{1-[Bis(4-chlorophenyl)methyl]azetidin-3-yl}-1-(3,5-difluorophenyl)-2,2-dimethylpropan-1-ol → HCID 67065942, compound

HRID 1724211Notes

Reaction equation

HRID 1724211 reaction equation
ClC1C=CC(C(C2C=CC(Cl)=CC=2)[N:9]2[CH2:12][CH:11]([C:13]([C:19]3[CH:24]=[C:23]([F:25])[CH:22]=[C:21]([F:26])[CH:20]=3)([OH:18])[C:14]([CH3:17])([CH3:16])[CH3:15])[CH2:10]2)=CC=1>C(Cl)Cl.C(O)(C(F)(F)F)=O>[NH:9]1[CH2:12][CH:11]([C:13]([C:19]2[CH:20]=[C:21]([F:26])[CH:22]=[C:23]([F:25])[CH:24]=2)([OH:18])[C:14]([CH3:15])([CH3:16])[CH3:17])[CH2:10]1

Participants

4

Reactant 1

HCID 111793371-{1-[Bis(4-chlorophenyl)methyl]azetidin-3-yl}-1-(3,5-difluorophenyl)-2,2-dimethylpropan-1-ol

Product 1

HCID 67065942HCID 67065942, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

To a solution of 210 mg (0.59 mmol) of tert-butyl 3-[1-(3,5-difluorophenyl)-1-hydroxy-2,2-dimethylpropyl]azetidine-1-carboxylate (2) in 1 mL of CH2Cl2, 1.5 mL of TFA was added and the solution was stirred for 1 h at rt. It was concentrated and washed with ether to afford the title compound as white solid; Mass Spectrum: m/e=256 (M+1).

Workup

  1. concentrationIt was concentrated
  2. washwashed with ether

Sources & evidence

ORD record
ord-e3f880870cff469cbe1f7ea460ffc999
Source dataset
uspto-grants-2009_02
Patent number
US07485732B2

Reaction notes

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