Ethanol, 1-bromo- → HCID 178480899, compound

HRID 1724609Notes

Reaction equation

HRID 1724609 reaction equation
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[S:4]/[C:3]/1=[N:11]/[N:12]=[CH:13][C:14]1[N:15]([CH3:19])[CH:16]=[CH:17][N:18]=1.[Br:20][CH:21]([OH:23])[CH3:22]>C(#N)C>[Br-:20].[OH:23][CH2:21][CH2:22][N+:18]1[CH:17]=[CH:16][N:15]([CH3:19])[C:14]=1/[CH:13]=[N:12]\[N:11]=[C:3]1\[S:4][C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[N:2]\1[CH3:1]

Participants

4

Reactant 2

HCID 14202443Ethanol, 1-bromo-HCID 87882107(E)-3-methyl-N-[(1-methylimidazol-2-yl)methylideneamino]-1,3-benzothiazol-2-imine

Product 1

HCID 178480899HCID 178480899, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

1.00 g (3.68 mmol) of 1-methyl-1H-imidazol-2-carboxaldehyde [(2E)-3-methyl-1,3-benzothiazol-2(3H)-ylidene] hydrazone from Step 1 and 0.69 g (5.52 mmol) of bromoethanol in acetonitrile were heated at reflux for 2 hours. After the solvent was removed, the precipitate formed was suction-filtered off, washed with ethyl acetate and dried under vacuum.

Workup

  1. temperatureat reflux for 2 hours
  2. customAfter the solvent was removed
  3. customthe precipitate formed
  4. filtrationwas suction-filtered off
  5. washwashed with ethyl acetate
  6. customdried under vacuum

Sources & evidence

ORD record
ord-bbd8fc960495476d8ef6e1a1b41ce03d
Source dataset
uspto-grants-2009_02
Patent number
US07488353B2

Reaction notes

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