Acetic Acid → HCID 67394311, compound

HRID 1724625Notes

Reaction equation

HRID 1724625 reaction equation
C([O:9][C@@H:10]1[C@H:14]([O:15]C(=O)C2C=CC=CC=2)[C@H:13]([CH2:24][O:25]C(=O)C2C=CC=CC=2)[O:12][C@H:11]1[N:34]1[CH:42]=[N:41][C:40]2[C:35]1=[N:36][CH:37]=[N:38][C:39]=2[CH3:43])(=O)C1C=CC=CC=1.O(C)[Na].C(O)(=O)C>CO>[CH3:43][C:39]1[N:38]=[CH:37][N:36]=[C:35]2[C:40]=1[N:41]=[CH:42][N:34]2[C@@H:11]1[O:12][C@@H:13]([CH2:24][OH:25])[C@@H:14]([OH:15])[C@H:10]1[OH:9]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 69081460HCID 69081460, compoundHCID 178418582HCID 178418582, compound

Product 1

HCID 67394311HCID 67394311, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To a solution of 1c (453 mg, 0.78 mmol) in MeOH (7 ml) at 5° C. is added dropwise 0.5 N NaOCH3 in MeOH (0.78 ml) over 5 min. After being stirred at room temperature for 2 h, the reaction solution is chilled to 5° C. and neutralized with glacial acetic acid. Pure 1d crystallized in two crops from this neutral solution as a white solid.

Workup

  1. customPure 1d crystallized in two crops from this neutral solution as a white solid

Sources & evidence

ORD record
ord-eb8868db613e43b9ba38b4ac0079f40b
Source dataset
uspto-grants-2009_02
Patent number
US07488598B2

Reaction notes

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