Acetic Acid → HCID 67394311, compound

Participants

Reaction Steps

To a solution of 1c (453 mg, 0.78 mmol) in MeOH (7 ml) at 5° C. is added dropwise 0.5 N NaOCH3 in MeOH (0.78 ml) over 5 min. After being stirred at room temperature for 2 h, the reaction solution is chilled to 5° C. and neutralized with glacial acetic acid. Pure 1d crystallized in two crops from this neutral solution as a white solid.

Provenance & Evidence