Hydrochloric Acid → 1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(5-methyl-4-(6-oxo-1,6-dihydropyridin-3-yl)pyrimidin-2-yl)cyclopropanecarboxamide

HRID 172469Notes

Reaction equation

HRID 172469 reaction equation
[CH2:34]1[O:35][CH2:36][CH2:37][O:38][CH2:39]1.[ClH:33].[F:1][C:2]1([F:32])[O:3][c:4]2[c:5]([cH:7][cH:8][c:9]([C:11]3([C:14](=[O:15])[NH:16][c:17]4[n:18][cH:19][c:20]([CH3:31])[c:21](-[c:23]5[cH:24][n:25][c:26]([O:29][CH3:30])[cH:27][cH:28]5)[n:22]4)[CH2:12][CH2:13]3)[cH:10]2)[O:6]1>>[F:1][C:2]1([F:32])[O:3][c:4]2[c:5]([cH:7][cH:8][c:9]([C:11]3([C:14](=[O:15])[NH:16][c:17]4[n:18][cH:19][c:20]([CH3:31])[c:21](-[c:23]5[cH:24][nH:25][c:26](=[O:29])[cH:27][cH:28]5)[n:22]4)[CH2:12][CH2:13]3)[cH:10]2)[O:6]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 578561031-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(4-(6-methoxypyridin-3-yl)-5-methylpyrimidin-2-yl)cyclopropanecarboxamide

Product 1

HCID 578561171-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(5-methyl-4-(6-oxo-1,6-dihydropyridin-3-yl)pyrimidin-2-yl)cyclopropanecarboxamide

Sources & evidence

ORD record
ord-bc57d2237d5e451bad00be126c4f98e3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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