Triethylamine → HCID 178472172, compound

HRID 1724707Notes

Reaction equation

HRID 1724707 reaction equation
C(N(CC)CC)C.[F:8][C:9]1[CH:17]=[C:16]([F:18])[C:15]([F:19])=[CH:14][C:10]=1[C:11](Cl)=[O:12].[CH:20]1([NH:25][C:26]([CH3:33])=[CH:27][C:28]([O:30][CH2:31][CH3:32])=[O:29])[CH2:24][CH2:23][CH2:22][CH2:21]1>O1CCOCC1>[CH:20]1([NH:25][C:26]([CH3:33])=[C:27]([C:11](=[O:12])[C:10]2[CH:14]=[C:15]([F:19])[C:16]([F:18])=[CH:17][C:9]=2[F:8])[C:28]([O:30][CH2:31][CH3:32])=[O:29])[CH2:21][CH2:22][CH2:23][CH2:24]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 1451642,4,5-Trifluorobenzoyl chlorideHCID 66962611Ethyl 3-(cyclopentylamino)buta-2-enoate

Product 1

HCID 178472172HCID 178472172, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
65 °C

Procedure

Under ice cooling, triethylamine and 2,4,5-trifluorobenzoyl chloride were added to a solution of ethyl 3-(cyclopentylamino)buta-2-enoate in dioxane, for stirring at ambient temperature for 30 minutes and at 65° C. for one hour, to obtain ethyl 3-(cyclopentylamino)-2-(2,4,5-trifluorobenzoyl)buta-2-enoate.

Sources & evidence

ORD record
ord-a74a10861c204c4ea7edab78d2610844
Source dataset
uspto-grants-2009_02
Patent number
US07488739B2

Reaction notes

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