Hydrochloric Acid → HCID 86023720, compound

HRID 1724712Notes

Reaction equation

HRID 1724712 reaction equation
[N+:1]([O-])([O-])=O.[Na+].Cl.[F:7][C:8]1[CH:9]=[C:10]([CH:12]=[CH:13][C:14]=1[F:15])[NH2:11].[C:16]([CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])#[N:17].C([O-])(=O)C.[Na+]>CCO>[C:16]([CH:18]([N:1]=[N:11][C:10]1[CH:12]=[CH:13][C:14]([F:15])=[C:8]([F:7])[CH:9]=1)[C:19]([O:21][CH2:22][CH3:23])=[O:20])#[N:17]

Participants

7

Reactant 5

HCID 313Hydrochloric AcidHCID 7764Ethyl cyanoacetateHCID 24268Sodium NitrateHCID 774693,4-DifluoroanilineHCID 517045Sodium Acetate

Product 1

HCID 86023720HCID 86023720, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

An aqueous solution of sodium nitrate was added dropwise to an aqueous hydrochloric acid solution of 3,4-difluoroaniline under ice cooling, for stirring at the same temperature for 1.5 hours. The resulting reaction mixture was added dropwise to an aqueous EtOH solution of ethyl cyanoacetate and sodium acetate as prepared in a separate reaction flask, for stirring at ambient temperature for 2 hours, to obtain ethyl cyano[(3,4-difluorophenyl)diazenyl]acetate.

Workup

  1. customThe resulting reaction mixture
  2. customas prepared in a separate reaction flask
  3. stirringfor stirring at ambient temperature for 2 hours

Sources & evidence

ORD record
ord-d4ea106c30f947aa99b7ca2991392de5
Source dataset
uspto-grants-2009_02
Patent number
US07488739B2

Reaction notes

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