Hydrogen chloride-ethyl acetate → HCID 66962536, compound

HRID 1724718Notes

Reaction equation

HRID 1724718 reaction equation
[CH:1]1([NH:7][C:8]2[CH:17]=[C:16]3[C:11]([C:12](=[O:38])[C:13]([C:23]([NH:25][C@H:26]([CH2:31][C:32]4[CH:33]=[N:34][CH:35]=[CH:36][CH:37]=4)[C:27]([O:29][CH3:30])=[O:28])=[O:24])=[CH:14][N:15]3[CH:18]([CH2:21][CH3:22])[CH2:19][CH3:20])=[CH:10][C:9]=2[F:39])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:40].CCOC(C)=O>CCOC(C)=O>[ClH:40].[CH:1]1([NH:7][C:8]2[CH:17]=[C:16]3[C:11]([C:12](=[O:38])[C:13]([C:23]([NH:25][C@H:26]([CH2:31][C:32]4[CH:33]=[N:34][CH:35]=[CH:36][CH:37]=4)[C:27]([O:29][CH3:30])=[O:28])=[O:24])=[CH:14][N:15]3[CH:18]([CH2:19][CH3:20])[CH2:21][CH3:22])=[CH:10][C:9]=2[F:39])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 66962537HCID 66962537, compound

Product 1

HCID 66962536HCID 66962536, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

374 mg of methyl (2R)-2-({[7-(cyclohexylamino)-1-(1-ethylpropyl)-6-fluoro-4-oxo-1,4-dihydroquinolin-3-yl]carbonyl}amino)-3-pyridin-3-ylpropanoate was suspended in 4 ml of EtOAc, to which 2 ml of 0.5M HCl EtOAc solution was added, for stirring for 30 minutes. Subsequently, the resulting precipitate was filtered, to obtain 156 mg of methyl (2R)-2-({[7-(cyclohexylamino)-1-(1-ethylpropyl)-6-fluoro-4-oxo-1,4-dihydroquinolin-3-yl]carbonyl}amino)-3-pyridin-3-ylpropanoate hydrochloride.

Workup

  1. additionwas added
  2. filtrationSubsequently, the resulting precipitate was filtered

Sources & evidence

ORD record
ord-2e63be379a1f40b785883348fd6e88fc
Source dataset
uspto-grants-2009_02
Patent number
US07488739B2

Reaction notes

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