HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-Pyrrole-2-carboxylic acid, 5-methyl-, ethyl ester → 5-Methyl-4-(3-naphthalen-2-yl-acryloyl)-1H-pyrrole-2-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-Pyrrole-2-carboxylic acid, 5-methyl-, ethyl ester | HCID 96598 | — |
| Reactant | 3-(Naphthalen-2-yl)prop-2-enoyl chloride | HCID 53928395 | — |
| Product | 5-Methyl-4-(3-naphthalen-2-yl-acryloyl)-1H-pyrrole-2-carboxylic acid ethyl ester | HCID 66922127 | — |
Reaction Steps
5-Methyl-4-(3-naphthalen-2-yl-acryloyl)-1H-pyrrole-2-carboxylic acid ethyl ester (132) was synthesized from 5-methyl-1H-pyrrole-2-carboxylic acid ethyl ester (107) and-3-naphthalen-2-yl-acryloyl chloride following the procedure described in Example 32. Reaction conditions: 1,2-dichloromethane/−40° C.→RT. Purification: no purification. LC/MS: 40%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07488747B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-acf4865560594c8da3b1f61262aa9cd4 |
| Source note | uspto-grants-2009_02 |