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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1724841Generated: October 31, 2026

Hydrochloric Acid → HCID 178516409, compound

https://huagongshe.com/reaction/1724841

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant2-methoxy-7-[3-(trifluoromethyl)pyridin-2-yl]-N-[5-(trifluoromethyl)pyridin-2-yl]-[1,8]naphthyridin-4-amineHCID 57561047—
SolventDiethyl EtherHCID 3283—
SolventIsopropanolHCID 3776—
ProductHCID 178516409HCID 178516409—

Reaction Steps

Heat 2-methoxy-7-[3-(trifluoromethyl)pyridin-2-yl]-N-[5-(trifluoromethyl)pyridin-2-yl]-[1,8]naphthyridin-4-amine (128 mg), 1M hydrochloric acid in ether (0.25 mL) and isopropanol at 80° C. overnight. Cool and collect the precipitate by filtration to give the hydrochloride salt of the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07488740B2
Source datasetuspto-grants-2009_02
ORD IDord-3ce1e03fe3054168b3048faaddd5f317
Source noteuspto-grants-2009_02