Hydrochloric Acid → HCID 178516409, compound

HRID 1724841Notes

Reaction equation

HRID 1724841 reaction equation
C[O:2][C:3]1[CH:12]=[C:11]([NH:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][N:15]=2)[C:10]2[C:5](=[N:6][C:7]([C:24]3[C:29]([C:30]([F:33])([F:32])[F:31])=[CH:28][CH:27]=[CH:26][N:25]=3)=[CH:8][CH:9]=2)[N:4]=1.Cl>CCOCC.C(O)(C)C>[F:33][C:30]([F:31])([F:32])[C:29]1[C:24]([C:7]2[N:6]=[C:5]3[C:10]([C:11]([NH:13][C:14]4[CH:19]=[CH:18][C:17]([C:20]([F:21])([F:22])[F:23])=[CH:16][N:15]=4)=[CH:12][C:3]([OH:2])=[N:4]3)=[CH:9][CH:8]=2)=[N:25][CH:26]=[CH:27][CH:28]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 575610472-methoxy-7-[3-(trifluoromethyl)pyridin-2-yl]-N-[5-(trifluoromethyl)pyridin-2-yl]-[1,8]naphthyridin-4-amine

Product 1

HCID 178516409HCID 178516409, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 3776IsopropanolSolvent

Procedure

Heat 2-methoxy-7-[3-(trifluoromethyl)pyridin-2-yl]-N-[5-(trifluoromethyl)pyridin-2-yl]-[1,8]naphthyridin-4-amine (128 mg), 1M hydrochloric acid in ether (0.25 mL) and isopropanol at 80° C. overnight. Cool and collect the precipitate by filtration to give the hydrochloride salt of the title compound.

Workup

  1. temperatureCool
  2. customcollect the precipitate
  3. filtrationby filtration

Sources & evidence

ORD record
ord-3ce1e03fe3054168b3048faaddd5f317
Source dataset
uspto-grants-2009_02
Patent number
US07488740B2

Reaction notes

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