HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 2-chloro-7-[3-(trifluoromethyl)pyridin-2-yl]-N-[5-(trifluoromethyl) pyridin-2-yl]-[1,8]naphthyridin-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | HCID 178516409 | HCID 178516409 | — |
| Product | 2-chloro-7-[3-(trifluoromethyl)pyridin-2-yl]-N-[5-(trifluoromethyl) pyridin-2-yl]-[1,8]naphthyridin-4-amine | HCID 57561142 | — |
Reaction Steps
Heat 7-[3-(trifluoromethyl)pyridin-2-yl]-4-{[5-(trifluoromethyl)pyridin-2-yl]amino}-[1,8]naphthyridin-2-ol (112 mg) and phosphorus oxychloride (1 mL) at reflux for 1 hour. Evaporate to dryness, partition between ethyl acetate and saturated aqueous NaHCO3 and extract with EtOAc. Dry the combined organics over Na2SO4, concentrate under vacuum to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07488740B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-ce3901480faa4588900d52cfcf7c94b6 |
| Source note | uspto-grants-2009_02 |