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HRID1724842

反应详情

EQUATION

反应方程式

HRID 1724842 的结构方程式

REACTANTS

反应物

2
结构：O=P(Cl)(Cl)Cl
HCID24813

Phosphoric trichloride

Cl3OP

结构：Oc1cc(Nc2ccc(C(F)(F)F)cn2)c2ccc(-c3ncccc3C(F)(F)F)nc2n1
HCID178516409

未命名化合物

PRODUCTS

生成物

1
结构：FC(F)(F)c1ccc(Nc2cc(Cl)nc3nc(-c4ncccc4C(F)(F)F)ccc23)nc1
HCID57561142

未命名化合物

PROCEDURE

实验过程

Heat 7-[3-(trifluoromethyl)pyridin-2-yl]-4-{[5-(trifluoromethyl)pyridin-2-yl]amino}-[1,8]naphthyridin-2-ol (112 mg) and phosphorus oxychloride (1 mL) at reflux for 1 hour. Evaporate to dryness, partition between ethyl acetate and saturated aqueous NaHCO3 and extract with EtOAc. Dry the combined organics over Na2SO4, concentrate under vacuum to obtain the title compound.

WORKUP

后处理

  1. temperatureat reflux for 1 hour
  2. customEvaporate to dryness
  3. custompartition between ethyl acetate and saturated aqueous NaHCO3
  4. extractionextract with EtOAc
  5. dry with materialDry the combined organics over Na2SO4
  6. concentrationconcentrate under vacuum