反应详情

Dimethyl 1,3-acetonedicarboxylate (20.0 g, 115 mmol) is dissolved in a solution of 1,1,1,2-tetramethoxy-ethane (23.8 g, 158 mmol) and acetic anhydride (420 mL) and the solution is heated to reflux for 4 hours. The mixture is concentrated under reduced pressure. Toluene (200 mL) is added and the solvent removed under reduced pressure to yield the title compound.

1. temperaturethe solution is heated
2. temperatureto reflux for 4 hours
3. concentrationThe mixture is concentrated under reduced pressure
4. additionToluene (200 mL) is added
5. customthe solvent removed under reduced pressure