Dimethyl 3-oxoglutarate → 2-(1,2-Dimethoxy-ethylidene)-3-oxo-pentanedioic acid dimethyl ester

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Reaction Steps

Dimethyl 1,3-acetonedicarboxylate (20.0 g, 115 mmol) is dissolved in a solution of 1,1,1,2-tetramethoxy-ethane (23.8 g, 158 mmol) and acetic anhydride (420 mL) and the solution is heated to reflux for 4 hours. The mixture is concentrated under reduced pressure. Toluene (200 mL) is added and the solvent removed under reduced pressure to yield the title compound.

Provenance & Evidence