反应详情

温度

60 °C

2-(1,2-Dimethoxy-ethylidene)-3-oxo-pentanedioic acid dimethyl ester (29.8 g, 115 mmol) is dissolved in a solution of EtOH (250 mL), water (250 mL) and concentrated NH4OH(aq) (30 mL). The mixture is heated to 60° C. for 5 hours. The reaction mixture is cooled to room temperature and the EtOH removed under reduced pressure. The remaining aqueous solution is cooled in an ice bath and acidified with concentrated hydrochloric acid, at which time a white precipitate appeared. The precipitate is collected and dried in a vacuum oven to yield the title compound.

1. temperatureThe reaction mixture is cooled to room temperature
2. customthe EtOH removed under reduced pressure
3. temperatureThe remaining aqueous solution is cooled in an ice bath
4. customThe precipitate is collected
5. customdried in a vacuum oven