HCID 178494700, compound → HCID 178494546, compound

Participants

Reaction Conditions

Reaction Steps

4,6-Dihydroxy-2-methoxymethyl-5-nitro-nicotinic acid methyl ester (2.00 g, 7.75 mmol) is placed in concentrated hydrochloric acid (100 mL) and heated in a bomb at 120° C. overnight. The reaction mixture is cooled in an ice bath and poured onto ice (200 g). A white precipitate formed. The precipitate is collected and dried in a vacuum oven to afford the title compound.

Provenance & Evidence