反应详情

温度

120 °C

4,6-Dihydroxy-2-methoxymethyl-5-nitro-nicotinic acid methyl ester (2.00 g, 7.75 mmol) is placed in concentrated hydrochloric acid (100 mL) and heated in a bomb at 120° C. overnight. The reaction mixture is cooled in an ice bath and poured onto ice (200 g). A white precipitate formed. The precipitate is collected and dried in a vacuum oven to afford the title compound.

1. temperatureThe reaction mixture is cooled in an ice bath
2. additionpoured onto ice (200 g)
3. customA white precipitate formed
4. customThe precipitate is collected
5. customdried in a vacuum oven