HCID 57561099, compound → HCID 57561143, compound

HRID 1724853Notes

Reaction equation

HRID 1724853 reaction equation
[CH3:1][O:2][CH2:3][C:4]1[N:9]=[C:8]([NH2:10])[C:7]([N+:11]([O-])=O)=[C:6]([NH2:14])[CH:5]=1>CCO.[Pd]>[CH3:1][O:2][CH2:3][C:4]1[N:9]=[C:8]([NH2:10])[C:7]([NH2:11])=[C:6]([NH2:14])[CH:5]=1

Participants

4

Reactant 1

HCID 57561099HCID 57561099, compound

Product 1

HCID 57561143HCID 57561143, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

6-Methoxymethyl-3-nitro-pyridine-2,4-diamine (455 mg, 2.29 mmol) is dissolved in EtOH (50 mL) and 10% Pd/C (50 mg) is added. The mixture is hydrogenated at 50 psi for 2 hours. The reaction mixture is filtered through Celite and the Celite bed washed with EtOH (25 mL). The solvent is removed under reduced pressure to yield the title compound as an off-white solid.

Workup

  1. filtrationThe reaction mixture is filtered through Celite
  2. washthe Celite bed washed with EtOH (25 mL)
  3. customThe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-d1695c52de834c86a8d7f0a22c0808e9
Source dataset
uspto-grants-2009_02
Patent number
US07488740B2

Reaction notes

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