HCID 46203238, compound → HCID 178516376, compound

HRID 1724867Notes

Reaction equation

HRID 1724867 reaction equation
C[O:2][C:3]1[C:12]2[C:7](=[CH:8][C:9]([C:13]3[C:18]([C:19]([F:22])([F:21])[F:20])=[CH:17][CH:16]=[CH:15][N:14]=3)=[CH:10][CH:11]=2)[N:6]=[CH:5][CH:4]=1>Br.C(O)(=O)C>[F:21][C:19]([F:20])([F:22])[C:18]1[C:13]([C:9]2[CH:8]=[C:7]3[C:12]([C:3]([OH:2])=[CH:4][CH:5]=[N:6]3)=[CH:11][CH:10]=2)=[N:14][CH:15]=[CH:16][CH:17]=1

Participants

4

Reactant 1

HCID 46203238HCID 46203238, compound

Product 1

HCID 178516376HCID 178516376, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 260Hydrogen BromideSolvent

Procedure

Heat a solution of 4-methoxy-7-[3-(trifluoromethyl)pyridin-2-yl]quinoline (100 mg), in 33% hydrogen bromide in acetic acid (5 mL) at 100° C. for 18 hours. Evaporate to dryness to give the hydrobromide salt of the title compound.

Workup

  1. customEvaporate to dryness

Sources & evidence

ORD record
ord-84e1a85feb38473780e22b3976fff3f8
Source dataset
uspto-grants-2009_02
Patent number
US07488740B2

Reaction notes

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