反应详情

Dissolve 2,3,4-triaminopyridine (2.5 mmol) in water (20 mL). Add NaHCO3 (0.63 g, 7.5 mmol), dioxane (10 mL), and 2-bromo-1-(3-trifluoromethyl-pyridin-2-yl)-ethanone hydrobromide (0.5 g) and stir at 100° C. for 2 hours. Cool the mixture and extract with EtOAc (4×10 mL). Wash the combined organic extracts with brine and dry over Na2SO4. Purify the residue by preparative HPLC to give the title compound.

1. temperatureCool the mixture
2. extractionextract with EtOAc (4×10 mL)
3. washWash the combined organic extracts with brine
4. dry with materialdry over Na2SO4
5. customPurify the residue by preparative HPLC