Butyl bromide → HCID 11539228, compound

HRID 1724922Notes

Reaction equation

HRID 1724922 reaction equation
[N:1]12[CH2:8][CH2:7][C:4]([C:9]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[OH:10])([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[Br:23][CH2:24][CH2:25][CH2:26][CH3:27]>CC#N>[Br-:23].[CH2:24]([N+:1]12[CH2:6][CH2:5][C:4]([C:9]([OH:10])([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=3)([CH2:3][CH2:2]1)[CH2:7][CH2:8]2)[CH2:25][CH2:26][CH3:27]

Participants

4

Reactant 2

HCID 8002Butyl bromideHCID 239923851-Azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol

Product 1

HCID 11539228HCID 11539228, compoundYield 70.7%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Following the general procedure outlined in Example 3, 1-azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol (0.0496 g, 0.169 mmol) and 1-bromobutane (0.030 mL, 0.279 mmol) in 2 CH3CN/3 CHCl3 (4.0 mL) were reacted to give the desired product (0.0509 g, 70.7%). EI-MS m/z 350(M+) Rt (1.83 min).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-cdbea9f4225d4c55bcc9db50b02f2640
Source dataset
uspto-grants-2009_02
Patent number
US07488827B2

Reaction notes

Loading…