1,2-Dichloroethane → 4-Quinazolinamine,6-iodo-n-[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]-,hydrochloride

HRID 1725130노트

반응식

HRID 1725130 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([NH2:16])[CH:5]=[CH:6][C:7]=1[O:8][C:9]1[CH:10]=[N:11][C:12]([CH3:15])=[CH:13][CH:14]=1.[Cl:17][C:18]1[C:27]2[C:22](=[CH:23][CH:24]=[C:25]([I:28])[CH:26]=2)[N:21]=[CH:20][N:19]=1.ClCCCl>CC(O)(C)C>[ClH:17].[I:28][C:25]1[CH:26]=[C:27]2[C:22](=[CH:23][CH:24]=1)[N:21]=[CH:20][N:19]=[C:18]2[NH:16][C:4]1[CH:5]=[CH:6][C:7]([O:8][C:9]2[CH:10]=[N:11][C:12]([CH3:15])=[CH:13][CH:14]=2)=[C:2]([CH3:1])[CH:3]=1

참가 물질

5

반응물 3

HCID 111,2-DichloroethaneHCID 111738094-Chloro-6-iodoquinazolineHCID 114244343-Methyl-4-((6-methylpyridin-3-yl)oxy)aniline

생성물 1

HCID 666233074-Quinazolinamine,6-iodo-n-[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]-,hydrochloride수율 76%

시약·촉매·용매 1

HCID 6386tert-Butanol용매

반응 조건

온도
0 °C

실험 절차

A mixture of 3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamine (4.96 g, 23.18 mmol), 4-Chloro-6-iodo-quinazoline 604 g, 22.06 mmol) in tBuOH (60 mL) and DCE (60 mL) was refluxed for 6 hours. The reaction was cooled to 0° C. and the solid product (8.44 g, 76%) was isolated by filtration and washed with cold CH2Cl2 (50 mL).

출처 및 근거

ORD 기록
ord-ed24a877230a4b0eb11147cdb239979c
출처 데이터셋
uspto-grants-2009_02
특허 번호
US07488823B2

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