Piperidine → HCID 178486868, compound

HRID 1725140Notes

Reaction equation

HRID 1725140 reaction equation
[NH:1]1CCCC[CH2:2]1.[NH2:7][C:8]1[CH:16]=[C:15]([O:17][CH3:18])[C:14]([OH:19])=[CH:13][C:9]=1[C:10](O)=[O:11].N1C=CC=NN=1>CO>[CH3:18][O:17][C:15]1[CH:16]=[C:8]2[C:9]([C:10]([OH:11])=[N:1][CH:2]=[N:7]2)=[CH:13][C:14]=1[OH:19]

Participants

5

Reactant 3

HCID 8082PiperidineHCID 1230471,2,3-TriazineHCID 198070282-Amino-5-hydroxy-4-methoxybenzoic acid

Product 1

HCID 178486868HCID 178486868, compoundYield 107.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Piperidine (3 mL, 31 mmol) was added to a mixture of 2-Amino-5-hydroxy-4-methoxy-benzoic acid (8.1 g, 44.26 mmol) and triazine (5.38 g, 66.4 mmol) in MeOH (60 mL). The reaction was then heated to reflux and stir for 6 hours. The reaction was cool to 0oC. The product was isolated by filtration and washed with cold MeOH to give 6.37 g (33.2 mmol, 75%) of desired product.

Workup

  1. temperatureThe reaction was then heated
  2. temperatureto reflux
  3. temperatureThe reaction was cool to 0oC
  4. customThe product was isolated by filtration
  5. washwashed with cold MeOH

Sources & evidence

ORD record
ord-ca545d2dde784ebba67ecf244d8b47e0
Source dataset
uspto-grants-2009_02
Patent number
US07488823B2

Reaction notes

Loading…