Acetic Anhydride → HCID 178486873, 화합물

HRID 1725141노트

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HRID 1725141 반응식
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([OH:13])=[N:8][CH:9]=[N:10]2)=[CH:5][C:4]=1[OH:14].[CH3:15][C:16](OC(C)=O)=[O:17]>N1C=CC=CC=1>[OH:13][C:7]1[C:6]2[C:11](=[CH:12][C:3]([O:2][CH3:1])=[C:4]([O:14][C:16](=[O:17])[CH3:15])[CH:5]=2)[N:10]=[CH:9][N:8]=1

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 178486868HCID 178486868, 화합물

생성물 1

HCID 178486873HCID 178486873, 화합물수율 100%

시약·촉매·용매 1

HCID 1049Pyridine용매

반응 조건

온도
100 °C

실험 절차

A mixture of 7-Methoxy-quinazoline-4,6-diol (6.2 g, 32.3 mmol), Ac2O (100 mL) and pyridine (10 mL) was heat to 100° C., and stirred for 3 hours. The reaction was then cooled to room temperature and poured to ice water (300 mL). The product was isolated by filtration, washed with water (200 mL) and dried to give 7.61 g (32.4 mmol, 100%) of desired product.

후처리

  1. temperatureThe reaction was then cooled to room temperature
  2. customThe product was isolated by filtration
  3. washwashed with water (200 mL)
  4. customdried

출처 및 근거

ORD 기록
ord-9924a662dcd040619698ec3f509c5052
출처 데이터셋
uspto-grants-2009_02
특허 번호
US07488823B2

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