Water → HCID 57423674, compound

HRID 1725161Notes

Reaction equation

HRID 1725161 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:19])[CH2:9][CH2:10][C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:12])=[CH:4][CH:3]=1.[NH:20]1[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1.O>CS(C)=O>[C:13]1([C:11](=[O:12])[CH2:10][CH2:9][C:8]([C:5]2[CH:6]=[CH:7][C:2]([N:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)=[CH:3][CH:4]=2)=[O:19])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

5

Reactant 3

HCID 962WaterHCID 8082PiperidineHCID 57423673HCID 57423673, compound

Product 1

HCID 57423674HCID 57423674, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

1-(4-Fluoro-phenyl)-4-phenyl-butane-1,4-dione (390 mmol, 100 mg) and piperdine (3.9 mmol, 0.34 mL) are dissolved in DMSO (100 uL) in a vial. The vial is capped and allowed to heat/shake at 110° overnight. After which time, the reaction is checked by HPLC. After the reaction cooled to room temperature, 500 uL of water is added. The product precipitates and is filtered. 74 mg is collected and confirmed by LCMS.

Workup

  1. customThe vial is capped
  2. temperatureto heat/shake at 110° overnight
  3. customThe product precipitates
  4. filtrationis filtered
  5. custom74 mg is collected

Sources & evidence

ORD record
ord-09448d6fb2d2442e8c6b42a74276e83a
Source dataset
uspto-grants-2009_02
Patent number
US07488832B2

Reaction notes

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